Appendices: Real-world treatment, clinical outcomes and healthcare resource utilization among persons with hemophilia A by age

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posted on 2024-01-03, 13:50 authored by Eleanor O Caplan, Anisha M. Patel, Richard W DeClue, Marina Sehman, Daniel Cornett, Tiffany Fair Shaffer, Karina Raimundo, Brandon T Suehs

These are peer-reviewed appendices for the article 'Real-world treatment, clinical outcomes and healthcare resource utilization among persons with hemophilia A by age' published in the Journal of Comparative Effectiveness Research.

Appendix A. NDC, GPI, and HCPCS Codes for Hemophilia-related Therapies.
Appendix B. ICD-9/10 and CPT Codes for Hemophilia-related Diagnoses and Events.
Appendix C. Exclusions.
Appendix D. LOINC Codes.
Appendix E. ICD-9/10 Procedure and CPT Codes for Joint Procedures and Surgery.
Appendix F. Fracture Codes.

Summary: Aim: Examine real-world characteristics, treatment patterns, and outcomes among treated persons with hemophilia A (PwHA) stratified by age. Patients & methods: This study utilized US claims data from 1 January 2007–31 July 2018 from the Humana Research Database. Unadjusted comparisons were conducted across PwHA (<18, 18–55, 56–89 years) enrolled in commercial or Medicare Advantage Prescription Drug plans. Results: A total of 294 PwHA were identified; 21.1% experienced ≥1 bleeding event, and 41.2 and 53.1% had evidence of arthropathy or related disorders, and pain, respectively. Along with all-cause and hemophilia-related healthcare resource utilization (HCRU), these were highest among PwHA aged 56–89 years. Conclusion: Insights into treatment, outcomes and HCRU may identify opportunities for enhanced disease management, particularly in older PwHA.