Supplemental tables: Clinical manifestations and healthcare utilization before diagnosis of transthyretin amyloidosis

These are peer-reviewed supplementary materials for the article 'Clinical manifestations and healthcare utilization before diagnosis of transthyretin amyloidosis' published in the Journal of Comparative Effectiveness Research.

• Supplemental Table I: Diagnostic testing and therapeutic procedures during three years prior to diagnosis
• Supplemental Table II: Healthcare utilization during three years prior to diagnosis

Introduction: Initial clinical manifestations of transthyretin amyloidosis (ATTR) are not well understood, making timely diagnosis challenging. Methods: Patients aged ≥68 years newly diagnosed with ATTR were identified using Medicare Research Identifiable Files. Symptom manifestation and healthcare utilization were measured during 3 years pre-diagnosis; demographics and comorbidity index during 1-year prediagnosis. Controls (ATTR-free) werematched 1:1 to patientswith ATTR based on age, sex and region; same index date and enrollment as match. Results: We identified 552 matched ATTR-control pairs: mean age 78.3 (standard deviation 6.3) and 64.5% male. Among patients with ATTR (vs controls), cardiovascular conditions (92.9 vs 75.9%) and hospitalization (54.0 vs 35.5%) were frequent during 3 years pre-diagnosis. Conclusion: Patients with ATTR have multiple symptoms and hospitalizations pre-diagnosis, recognition of which may facilitate earlier diagnosis and treatment.