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Supplementary data: A value-based budget impact model for dronedarone compared with other rhythm control strategies

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posted on 2024-04-12, 14:28 authored by Jennifer Ken-Opurum, Sesha Srinivas, Pratyusha Vadagam, Lang Faith, Seojin Park, Scott Charland, Andrew Revel, Ronald Preblick

Supplementary Table 1: Annual Rate control costs associated with AADs and Annual ablation cost associated with AADs

  • Supplementary Table 2: Risk of LTCOs for AADs
  • Supplementary Table 3: Event Risks Associated with Dronedarone vs. Rate Control + Ablation
  • Supplementary Table 4: Event Risks Associated with Dronedarone vs. Ablation
  • Supplementary Table 5: Event Risks Associated with Dronedarone + Rate Control vs. AADs + Rate Control
  • Supplementary Table 6: Event Risks Associated with Dronedarone vs. Rate Control
  • Supplementary Table 7: Event Risks Associated with Dronedarone + Ablation vs. other AADs + Ablation
  • Supplementary Table 8: Event Risks Associated with Dronedarone + Rate Control + Ablation vs. AADs + Rate Control + Ablation
  • Supplementary Table 9: Event Risks Associated with Dronedarone vs. Rate Control vs. Ablation
  • Supplementary Table 10: Event Risks for Temporal Scenarios

Aim: The budgetary consequences of increasing dronedarone utilization for treatment of atrial fibrillation were evaluated from a US payer perspective. Materials & methods: A budget impact model over a 5-year time horizon was developed, including drug-related costs and risks for long-term clinical outcomes (LTCOs). Treatments included antiarrhythmic drugs (AADs; dronedarone, amiodarone, sotalol, propafenone, dofetilide, flecainide), rate control medications, and ablation. Direct comparisons and temporal and non-temporal combination scenarios investigating treatment order were analyzed as costs per patient per month (PPPM). Results: By projected year 5, costs PPPM for dronedarone versus other AADs decreased by $37.69 due to fewer LTCOs, treatment with dronedarone versus ablation or rate control medications + ablation resulted in cost savings ($359.94 and $370.54, respectively), and AADs placed before ablation decreased PPPM costs by $242 compared with ablation before AADs. Conclusion: Increased dronedarone utilization demonstrated incremental cost reductions over time.


Funding

This study was funded by Sanofi and conducted by Sanofi & Axtria.

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