Supplementary material: Prognostic and predictive value of microsatellite instability status among patients with colorectal cancer

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posted on 2024-01-03, 16:41 authored by Firas Baidoun, Anas M Saad, Omar Abdel-Rahman

This is a peer-reviewed supplementary table for the article 'Prognostic and predictive value of microsatellite instability status among patients with colorectal cancer' published in the Journal of Comparative Effectiveness Research.

Supplementary Figure 1. Overall survival in (A) stage II CRC and (B) stage III patients according to MSI status.
Supplementary Figure 2. Stage II CRC with high-risk features.
Supplementary Figure 3. Overall survival in (A) MSI-H and (B) MSI-S stage II CRC patients with highest-risk features according to chemotherapy.
Supplementary Figure 4. Stage II CRC without high-risk features.
Supplementary Figure 5. Overall survival in (A) MSI-H stage III CRC patients with low-risk features and (B) MSI-H stage III CRC patients with high-risk features according to chemotherapy.
Supplementary Figure A. Patient selection.
Supplementary Figure B. Histogram for raw data and matched data (stage II MSI-H and high-risk features).
Supplementary Figure C. Histogram for raw data and matched data (stage II MSI-H and without high-risk features).
Supplementary Figure D. Histogram for raw data and matched data (stage II MSI-S and without high-risk features).
Supplementary Table A. Baseline characteristics of MSI-H stage II CRC patients with high-risk features according to chemotherapy after propensity score matching.
Supplementary Table B. Baseline characteristics of MSI-H stage II CRC patients without high-risk features according to chemotherapy after propensity score matching.
Supplementary Table C. Baseline characteristics of MSI-L stage II CRC patients without high-risk features according to chemotherapy after propensity score matching.
Supplementary Table D. Multivariate analysis for MSI known status stage II & III CRC patients.

Summary: Objectives: Compare overall survival (OS) between microsatellite instability (MSI) high and MSI-stable and analyze the effect of chemotherapy on OS. Methods: National cancer database was queried for patients diagnosed with colorectal adenocarcinoma between 2010 and 2016. We evaluated the OS and the chemotherapy effect using Kaplan–Meier estimates and multivariate Cox regression analyses. Results: Total of 30,436 stage II patients and 30,302 stage III patients were included. In stage II with high-risk features and MSI-high, patients who received chemotherapy had better OS compared to patients who didn't receive chemotherapy. The same was found in stage II with no high-risk features and MSI-high group. Conclusion: Stage II colorectal cancer patients with high-risk features and MSI-high who received chemotherapy have better OS compared to patients who didn't receive chemotherapy.