Supplementary materials: Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany

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posted on 2024-05-02, 15:17 authored by Thomas Wilke, Burkhard Weisser, Hans-Georg Predel, Roland Schmieder, Sven Wassmann, Anton Gillessen, Jorg Blettenberg, Ulf Maywald, Olaf Randerath, Sabrina Muller, Michael Bohm

These are peer-reviewed supplementary materials for the article 'Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany' published in the Journal of Comparative Effectiveness Research.

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Aim: This study assessed whether a single pill combination (SPC) is associated with lower direct healthcare costs. Materials & methods: Anonymized claims data of patients ≥18 years treated with drugs for cardiovascular (CV)-related diseases either as a single pill combination or multi-pill combination (follow up to 1 year) were evaluated. After propensity score matching, 59,336 out of 1,369,840 patients were analyzed. Results: In all cohorts, patients receiving a single pill combination had a lower frequency of general practitioner and specialist visits. The patients also had a significantly lower ratio of all-cause hospitalization days and number of CV-related prescriptions as well as all-cause prescriptions (with one exception) compared with those receiving a multi-pill combination. Conclusion: Direct CV-related costs were significantly lower in four out of seven comparisons, with a trend toward lower costs in the other three comparisons.