Supplementary materials: Impact analysis of expanding narrow-spectrum antibiotic use for children with ear, sinus and throat infections

<p dir="ltr"><b>These are peer-reviewed supplementary tables for the article '</b><b>Impact analysis of expanding narrow-spectrum antibiotic use for children with ear, sinus and throat infections</b><b>' published in the</b><b> </b><b><i>Journal of Comparative Effectiveness Research</i></b><b>.</b></p><ul><li><b>Table A-1. </b>Complete Set of Parameters Used in the Model.</li><li><b>Table A-2. </b>Ranges Used for One-Way Sensitivity Analysis and Distributions Used for Probabilistic Sensitivity Analysis.</li></ul><p dir="ltr"><b>Summary: Aim:</b> Estimate the impacts treating acute respiratory tract infections (ARTIs) in children aged 6 months through 12 years with narrow-spectrum antibiotics. <b>Materials & methods:</b> Decision-tree model to estimate children’s health, healthcare utilization and costs, and caregiver’s time and costs for using narrow-spectrum antibiotics in eligible children with an ARTI, compared with current use of narrow- and broad-spectrum antibiotics. <b>Results:</b> Reduced adverse drug reactions by 35,750 (14%) cases) and 4750 (12%) fewer emergency department visits, 300 (12%) fewer hospitalizations, and 50,500 (10%) avoided outpatient visits. Annual healthcare costs fell by US$120 million (22%). Total societal costs declined by US$131 million (20%). <b>Conclusion:</b> National implementation of narrow-spectrum antibiotics to treat ARTIs in children improves patient outcomes and reduces caregiver burden and annual healthcare costs.</p><br><p></p>