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Supplementary materials: Indirect treatment comparison of lurbinectedin versus other second-line treatments for small-cell lung cancer

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posted on 2024-04-12, 15:15 authored by Raj Hanvesakul, Badri Rengarajan, Navit Naveh, Anne Boccuti, Julie Park, Adekemi Adeyemi, Clyde Caisip, Jeroen Jansen, Florence Wilson

These are peer-reviewed supplementary materials for the article 'Indirect treatment comparison of lurbinectedin versus other second-line treatments for small-cell lung cancer' published in the Journal of Comparative Effectiveness Research.

  • Table S1: Eligibility criteria for screening
  • Table S2: Search strategy for Embase
  • Table S3: Search strategy for MEDLINE
  • Table S4: Search strategy for Cochrane Register of Controlled Trials
  • Table S5: Summary of absolute standardized difference and effective sample size when matched to the basket trial platinum-sensitive subgroup (n = 60)
  • Table S6: Estimated odds ratios and hazard ratios for overall survival and overall response rate across sensitivity analyses
  • Table S7: Estimated odds ratios from the fixed-effect network meta-analysis of hematological adverse events
  • Figure S1: Network of trials included in the feasibility assessment, with visualization of platinum sensitivity status
  • Figure S2: Evidence networks for overall response rate, overall survival, grade 3/4 anemia, grade 3/4 thrombocytopenia, and grade 3/4 neutropenia for (A) sensitivity analysis #1 and (B) sensitivity analysis #2
  • Figure S3: Results from network meta-analysis of progression-free survival/time to progression.

Aim: Compare lurbinectedin versus other second-line (2L) small-cell lung cancer (SCLC) treatments. Methods: An unanchored matching-adjusted indirect comparison connected the platinum-sensitive SCLC cohort of a single-arm lurbinectedin trial to a network of three randomized controlled trials (oral and intravenous [IV] topotecan, and platinum re-challenge) identified by systematic literature review. Network meta-analysis methods estimated relative treatment effects. Results: In platinum-sensitive patients, lurbinectedin demonstrated a survival benefit and favorable safety profile versus oral and IV topotecan and platinum re-challenge (overall survival, hazard ratio [HR]: 0.43; 95% credible interval [CrI]: 0.27, 0.67; HR: 0.43; 95% CrI: 0.26, 0.70; HR: 0.42; 95% CrI: 0.30, 0.58 respectively). Conclusion: Lurbinectedin showed a robust survival benefit and favorable safety versus other SCLC treatments in 2L platinum-sensitive SCLC.

Funding

This study was supported by Jazz Pharmaceuticals.

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