Supplementary tables: Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review

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posted on 2024-05-03, 16:03 authored by Corinne Duperrouzel, Coby Martin, Ari Mendell, Megan Bourque, Adam Carrera, Alicia Mack, Jeffrey Nesheim

These are peer-reviewed supplementary materials for the article 'Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review' published in the Journal of Comparative Effectiveness Research.

Supplementary Table 1: Search strategy
Supplementary Table 2: Quality evaluation of observational studies
Supplementary Table 3: Quality evaluation of economic studies
Supplementary Table 4: Detailed reporting of HCRU outcomes
Supplementary Table 5: Detailed reporting of cost outcomes

Aim: To determine the economic burden associated with anticholinergic medication use in adults with overactive bladder (OAB) in the USA. Methods: A systematic literature review was conducted to identify articles assessing healthcare resource utilization (HCRU) and costs associated with anticholinergic use in adults with OAB. Results: From the 34 articles identified, increased anticholinergic burden, switching anticholinergic treatments and potentially inappropriate anticholinergic use were associated with increased HCRU and/or costs. However, studies comparing patients with OAB receiving anticholinergics to individuals with untreated OAB or without OAB reported a mix of increases and decreases in HCRU and costs. Conclusion: Additional controlled studies assessing the economic impact of anticholinergics in OAB are needed and may enable optimization of economic and potentially patient outcomes.