Supplementary tables: Systematic review of outcomes and patient heterogeneity in relapsed or refractory diffuse large B-cell lymphoma
These are peer-reviewed supplementary materials for the article 'Systematic review of outcomes and patient heterogeneity in relapsed or refractory diffuse large B-cell lymphoma' published in the Journal of Comparative Effectiveness Research.
- Supplementary Table 1: PICOS criteria defining the scope of the current SLR
- Supplementary Table 2: Search strategies
- Supplementary table 3: MINORS assessments
- Supplementary table 4: Cochrane Risk of Bias 2 assessments
Aim: To evaluate trials of systemic therapies in transplant-ineligible or -experienced, relapsed/refractory diffuse large-B cell lymphoma and the impact of patient characteristics on overall response rate (ORR). Patients & methods: Systematically reviewed multiple databases through 22 July 2021. Analyzed variations in patient characteristics and their relationship with ORR across trials. Results: Among 17 included trials, key patient characteristics varied substantially: primary refractory (0–69%), refractory to last line of therapy (LOT) (12–100%), ≥2 prior LOTs (14–100%), ≥3 prior LOTs (0–64%), IPI ≥3 (23–73%), tumor stage III/IV (50–90%) and median age (56–74 years). ORRs varied substantially (25–83%), correlating with these characteristics. Conclusion: Differences in patient characteristics significantly contribute to the variability in ORR across these trials and should be considered when contextualizing efficacy data.
