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Supplementary figure: Real-world weight changes in people with HIV-1 at risk of weight gain (female, Black or Hispanic) switching from integrase strand transfer inhibitors

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posted on 2024-05-03, 15:43 authored by Prina Donga, Bruno Emond, Aditi Shah, Brahim K Bookhart, David Anderson, Maude Vermette-Laforme, Carmine Rossi, Marie-Helene Lafeuille

These are peer-reviewed supplementary materials for the article 'Real-world weight changes in people with HIV-1 at risk of weight gain (female, Black or Hispanic) switching from integrase strand transfer inhibitors' published in the Journal of Comparative Effectiveness Research.

  • Supplemental Figure 1: Study design

Aim: Compare weight changes between people living with HIV-1 (PLWH) at high risk of weight gain (females, Blacks or Hispanics) switching from an integrase strand transfer inhibitor (INSTI) to a protease inhibitor (PI) or another INSTI. Materials & methods: Mean weight changes from pre-switch to up-to-12 months post-switch were retrospectively compared between PLWH switching to a PI or INSTI. Results: 356 PLWH were eligible. At 9- and 12-month post-switch, weight increases were observed for INSTI (weight: +1.55 kg and +1.59 kg), while decreases were observed for PI (-0.23 kg and -1.59 kg); differences between cohorts widened over time. Conclusion: These data suggest that switching off an INSTI may be a management tool to mitigate or reverse weight gain.

Funding

This study was funded by Janssen Scientific Affairs, LLC.

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